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Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.
"at the heart of the inmunity"

TOLLerant Project - Newsletter July 2016

Toolerant 3rd Meeting 2016 3

location: National Institute of Chemistry (KI),
Ljubljana, Slovenia
14-16 December 2016.

more information will follow in the next newsletter (september 2016)


KI, Ljubljana, Slovenia
September 27-29, 2016

Promotional interactive event and hands-on introduction of departments for interested public, Department for Synthetic Biology and Immunology, National Institute of Chemistry, part of the Science festival week.

CIB-CSIC, Madrid, Spain
November 14 - 16th, 2016

Science Week. Workshops for High school students “The chemistry of the molecules of life: the 3D perspective". 14 and 16th Nov 2016.

DIOMUNE, Madrid, Spain
December 2016
II Annual Congress of National Association Biotechnological speakers (

Who we are and what we do at CIC- bioGUNE?

Dissemination Day at University of the Basque Country open to undergraduate students (Spanish language).


EuCheMS Chemistry Congress. Seville, Spain  2016.

-Jean-Marc Billod, CIB-CSIC : poster presentation. “TLR4: Molecular Recognition Event In Relation With Innate Immunity. Hopanoid-LPS Altering Membrane Properties.”

XV Meeting School on Carbohydrate Chemistry, Pontignano, Italy  19 - 22 June 2016.

-Clara Barrau, Mateusz Pallach, Flaviana Di Lorenzo, Antonio Molinaro, Alba Silipo - Università di Napoli Federico II (UNINA): “ Structure of potential agonist and antagonist LPS from extremophile bacteria PC-11.”

-Mateusz Pallach, Clara Barrau, Flaviana Di Lorenzo, Antonio Molinaro, Alba Silipo - Università di Napoli Federico II (UNINA):  “Structural studies on marine bacteria endozoicomonas sp. O-polysaccharide.”



- Analyzing Ensembles of Amyloid Proteins Using Bayesian Statistics.

Methods Mol Biol. 2016;1345:269-80. doi: 10.1007/978-1-4939-2978-8_17.
Gurry T, Fisher CK, Schmidt M, Stultz CM.

- Structural investigation of the lipopolysaccharide O-chain isolated from Burkholderia fungorum strain DSM 17061.

Carbohydr Res. 2016 Jul 9;433:31-35. doi: 10.1016/j.carres.2016.07.008. [Epub ahead of print]
De Felice A, Di Lorenzo F, Scherlach K, Ross C, Silipo A, Hertweck C, Molinaro A.

- Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5.

PLoS One. 2016 Jul 8;11(7):e0158894. doi: 10.1371/journal.pone.0158894.
Forstnerič V, Ivičak-Kocjan K, Ljubetič A, Jerala R, Benčina M.

- Conformational flexibility around the Gal-β-(1 → 3)-Glc linkage: Experimental evidence for the existence of the anti-ψ conformation in aqueous solution.

Carbohydr Res. 2016 Jul 5;433:36-40. doi: 10.1016/j.carres.2016.06.009. [Epub ahead of print]
Vidal P, Jiménez-Barbero J, Espinosa JF.

- Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a.

Chemistry. 2016 Jul 4. doi: 10.1002/chem.201600567. [Epub ahead of print]

Boutet J, Blasco P, Guerreiro C, Thouron F, Dartevelle S, Nato F, Cañada FJ, Ardá A, Phalipon A, Jiménez-Barbero J, Mulard LA.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642157

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