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Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.
"at the heart of the inmunity"

TOLLerant Project - Newsletter
December 2017

TOLLerant 5th MEETING – Ghent 2017


12th – 15th December, 2017. Ghent, Belgium

Meeting Venue: VIB-UGent Research Building

Address: Technologiepark 927; 9052 Gent-Zwijnaarde; Belgium

Organizing Committee: Rudi Beyaert and Yasmine Driege


VIB - dissemination activities

- December 12-15, 2017: VIB-Ghent: 5th Tollerant meeting

- VIB-Ghent (IRC) organizes a seminar cycle with outstanding international speakers. Most seminars take place on Friday, at 11.30 am

Recent Publications and AltMetric details




ESR Publications and oral/poster presentations


Lenny Zaffaroni

Poster presentation

-In vitro characterisation of synthetic Toll-like Receptor 4 modulators

Lenny Zaffaroni, Florent Cochet, Fabio Facchini, Matilde Forcella, Alberto Minotti, Harald Braun, Fabio Lapenta, Roman Jerala, Rudi Beyaert, Paola Fusi, Francesco Peri. EFMC-ASMC'17 (Aug 2017 – Vienna, Austria).

Oral presentation

-Production of human MD-2 and development of ligand binding assays for the characterization of Toll-Like Receptor 4 modulators

Lenny Zaffaroni. PhD meeting (Oct 2017 - Verbania, Italy).



Florent Cochet

Poster presentation

 -Synthesis of small-molecules modulator of innate immunity

Florent Cochet, Silvia Rapisarda, Fabio Facchini, Jean-Marc Billod, Sonsoles Martín Santamaría, Francesco Peri. 19th European Carbohydrate Symposium – EUROCARB, July 2nd -6th 2017 Barcelona (Spain)


-The Role of Carbohydrates in the Lipopolysaccharide (LPS) / Toll-Like Receptor 4 (TLR4) Signalling.

Int J Mol Sci. 2017 Nov 3;18(11), 2318-2334. pii: E2318. doi: 10.3390/ijms18112318.

Cochet, Florent; Peri, Francesco.



Sara Francisco

Poster presentation

-Involvement of TRIF in macrophage response to TLR2 ligands

Sara Francisco, Estefania Rodríguez-García, Gloria Gonzalez- Aseguinolaza, Manuel Fresno, Alicia Arranz.

Presented at:

-Meeting on Dendritic cells and Macrophages, 27-28 March 2017, CNB-CSIC, Spain.

-Meeting 47th Annual Meeting of the German Society for Immunology, 12–15 September 2017, Erlangen, Germany

-Meeting 31st Annual meeting of the European Macrophage and Dendritic Cell Society, 21st to 23rd of September 2017, CNIC, Spain

-Meeting 1st FEBS3+ Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies, 23-26 October 2017 in Barcelona, Spain




Mateusz Pallach and Clara Barrau


-Structure of the Lipopolysaccharide from the Bradyrhizobium sp. ORS285 rfaL Mutant Strain.

ChemistryOpen. 2017 Jun 12;6(4):541-553. doi: 10.1002/open.201700074.

F. Di Lorenzo, A. Palmigiano, K. A. Duda, M. Pallach, N. Busset, L. Sturiale, E. Giraud, D. Garozzo, A. Molinaro, A. Silipo.

-The Deep-Sea Polyextremophile Halobacteroides lacunaris TB21 Rough-Type LPS: Structure and Inhibitory Activity towards Toxic LPS.

Mar Drugs. 2017 Jun 27;15(7). pii: E201. doi: 10.3390/md15070201.

F. Di Lorenzo, A. Palmigiano, I. Paciello, M. Pallach, D. Garozzo, M.L. Bernardini, V. La Cono, M.M. Yakimov, A. Molinaro, A. Silipo.


Poster presentation

-Structure of potential agonist and antagonist LPS from extremophile bacteria

C. Barrau, F. Di Lorenzo, A. Molinaro, A. Silipo, EUROCARB, Barcelona, Spain, 2-6/07/2017

-Structural studies on Acetobacter pasteurianus CIP103108 and Zymomonas mobilis cell wall components

M. Pallach, F.Di Lorenzo, A.Molinaro, A.Silipo, 19th European Carbohydrate Symposium EUROCARB 2017, Barcelona, Spain, 2-6 July 2017


Oral Communications

-Structure of potential LPS agonists and antagonists from different bacterial sources

M. Pallach NapOsaka, Naples, 10 July 2017

-Structure of LPS from extremophile bacteria

 C. Barrau NapOsaka, Naples, 10 July 2017

-Structure of potential LPS agonists and antagonists from different bacterial sources

M. Pallach, Bioactive Polysaccharides Workshop, Cambridge, UK, 12-13 September 2017

Helena Coelho


-Glycans in Infectious Diseases. A Molecular Recognition Perspective.

Curr Med Chem. 2017 Nov 24;24(36):4057-4080. doi: 10.2174/0929867324666170217093702.

Luca Unione, Ana Gimeno, Pablo Valverde, Ilaria Calloni, Helena Coelho, Stefania Mirabella, Ana Poveda, Ana Arda, Jesús Jiménez-Barbero

Book Chapter:

-Recent advances in the application of NMR methods to uncover the conformation and recognition features of glycans.

Ana Ardá, Helena Coelho, Beatriz Fernández de Toro, Silvia Galante, Ana Gimeno, Ana Poveda, Javier Sastre, Luca Unione, Pablo Valverde, F. Javier Cañada, Jesús Jiménez-Barbero

DOI: 10.1039/9781782626657-00047.

Oral communication

-Synthesis and Preclinical Evaluation of Glycolipid-Based TLR4 Modulators: New Therapeutics for inflammatory and Autoimmune Diseases

Florent Cochet, Alberto Minotti, Fabio Facchini, Lenny Zaffaroni, Andrea Luraghi, Jean-Marc Billod, Sonsoles Martin-Santamaria, Gabriel Wang, Thomas Huser, Helena Coelho, Jesus Jimenez Barbero and Francesco Peri. 19th European Carbohydrate Symposium –EUROCARB2017. July 2-6, 2017. Barcelona, Spain.


Fabio Lapenta

Oral presentation

-Hierarchical self-assembly of a de novo heterodimeric coiled-coil-based bipyramidal protein cage.

Fabio Lapenta. 21.06.2017, Bioorigami – designed bionanostructures from nucleic acids to proteins and beyond. Ljubljana, Slovenia


-Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo.

Nat Biotechnol. 2017 Oct 16. doi: 10.1038/nbt.3994.

Ljubetič A, Lapenta F, Gradišar H, Drobnak I, Aupič J, Strmšek Ž, Lainšček D, Hafner-Bratkovič I, Majerle A, Krivec N, Benčina M, Pisanski T, Veličković TĆ, Round A, Carazo JM, Melero R, Jerala R.



Gabriel Wang

Oral presentation

-Introduction of Superresolution microscopy (nanoscopy) and its applications

Gabriel Wang. Invitation talk, 2 Oct. 2017, Ljubljana Slovenia.


Jean-Marc Billod

2-6/07/2017 EUROCARB symposium, Barcelona, Spain

Poster presentation

-TLR4 modulation by natural LPS and synthetic glycolipids. The computational perspective.

Jean-Marc Billod, Lucía Pérez-Regidor, Florent Cochet, Mateusz Pallach, Alba Silipo, Antonio Molinaro, Francesco Peri, Sonsoles Martín-Santamaría

12/07/2017 - 2nd ITN networking at CIB

Oral presentation

-TLR4 modulation: molecular recognition studies and drug design by molecular modelling.

Jean-Marc Billod

23-26/09/2017 – XL SEBBM Conference, Barcelona, Spain

Flash + poster

-Understanding and modulation of toll like receptor 4: computational approach

Jean-Marc Billod, Sonsoles Martín-Santamaría



-Gram‐Negative Extremophile Lipopolysaccharides: Promising Source of Inspiration for a New Generation of Endotoxin Antagonists.

European Journal of Organic Chemistry (2017).

Di Lorenzo, Flaviana, Jean‐Marc Billod, Sonsoles Martín‐Santamaría, Alba Silipo, and Antonio Molinaro.

-Amphiphilic guanidinocalixarenes inhibit lipopolysaccharide (LPS)-and lectin-stimulated Toll-like Receptor 4 (TLR4) signaling.

J Med Chem. 2017 Jun 22;60(12):4882-4892. doi: 10.1021/acs.jmedchem.7b00095.

Sestito, Stefania Enza, Fabio A. Facchini, Ilaria Morbioli, Jean-Marc Billod, Sonsoles Martin Santamaria, Alessandro Casnati, Francesco Sansone, and Francesco Peri.

-Current Challenges in the Computational Modelling of Molecular Recognition Processes

Lucía Pérez-Regidor, Joan Guzmán-Caldentey, Carlos F. Rodríguez, Jean-Marc Billod, Juan Nogales, and Sonsoles Martín-Santamaría. 2017.. In: S. Martín-Santamaría (Ed.). Computational Tools for Chemical Biology (pp. 221-246). Cambridge: Royal Society of Chemistry.



Aurora Holgado


-Unusual Lipid A from  a Cold-Adapted Bacterium: Detailed Structural Characterization.

Chembiochem. 2017 Sep 19;18(18):1845-1854. doi: 10.1002/cbic.201700287.

Casillo A, Ziaco M, Lindner B, Parrilli E, Schwudke D, Holgado A, Verstrepen

L, Sannino F, Beyaert R, Lanzetta R, Tutino ML, Corsaro MM.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642157

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