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Technology Development Fund selects seven Boston Children’s projects

Boston Children's Technology Development Fund (TDF) is proud to announce the selection of seven Boston Children's projects after its fifth funding cycle. Awarded projects span multiple healthcare sectors, including pharmaceutical, regenerative medicine, vaccine, medical device and healthcare IT. [Learn More]


A cell-free, silk-based scaffold for regenerating bladder tissue

Carlos Estrada, MD, and Joshua Mauney, PhD, are developing a new strategy to grow or augment bladders for patients with neurogenic bladder (due to spina bifida, spinal cord injuries, multiple sclerosis, Parkinson’s, etc.) or bladder cancer. Unlike earlier approaches, their silk-based biomaterial stimulates tissue generation without the need for a patient's own cells. This project received a 2013 Technology Development Fund award. [Learn More]

Highlighted Technologies

Device and methods for analyzing rodent behavior using light technology               

Research tool, Neuroscience, Pain, Instrumentation, Method of use

       Lead Investigator: Clifford Woolf, MD, PhD

Drug screening platform using conversion of somatic cells into nociceptors               

Therapeutics, Research tool, Neurology, Drug discovery, Platform

      Lead Investigator: Clifford Woolf, MD, PhD

Chemical inducer of dimerization cleavable by light               

Research tool, Drug discovery, Cell signaling 

     Lead Investigator: Thomas Schwarz, PhD

*To search the full list of technologies, click [here]

Newly Issued Patents

Stuart Orkin |  US 8,597,910  DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VWF, and VWF produced by the DNA, methods and cells

Richard Mulligan |  US 8,586,100  Populations of hematopoietic stem cells

Daniel Kohane |  US 8,609,733  Sensory-specific local anesthesia and prolonged duration local anesthesia

Selected Recent Scientific Publications

Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y. Role of Tet1 in erasure of genomic imprinting. Nature. 2013 Dec 19;504(7480):460-4. PMID: 24291790

Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12;504(7479):311-4. PMID: 24336288

Hammer PE, Pacak CA, Howe RD, Del Nido PJ. Straightening of curved pattern of collagen fibers under load controls aortic valve shape. J Biomech. 2013 Nov 28. PMID: 24315286

Kawahara G, Gasperini MJ, Myers JA, Widrick JJ, Eran A, Serafini PR, Alexander MS, Pletcher MT, Morris CA, Kunkel LM. Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet. 2013 Nov 28. PMID: 24234649

Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD. VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood. 2014 Jan 2;123(1):141-8. PMID: 24200682

Children's in the News

Boston Globe: For heart surgery, a glue replaces needle and thread

NPR: Gene therapy keeps 'bubble boy' disease at bay in eight children

Bio-IT World: The 'clear vision' of Claritas Genomics

Boston Globe: Potential new treatment for peanut allergies holds promise

Information Week: Patient discharge plans move out of the hospital

The mission of the Technology and Innovation Development Office (TIDO) is to translate the laboratory and clinical research excellence of Boston Children's Hospital into products for the public benefit. TIDO uses a multi-faceted approach to promote, support and develop research, technology and clinical innovations through the protection and licensing of intellectual property, investing in Boston Children's technologies, and establishing strong research and development partnerships with industry throughout the innovation to product life cycle.

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